Precision and Immunoprevention Strategies for Tobacco-Related Head and Neck Cancer Chemoprevention.

TitlePrecision and Immunoprevention Strategies for Tobacco-Related Head and Neck Cancer Chemoprevention.
Publication TypeJournal Article
Year of Publication2021
AuthorsCentuori SM, Caulin C, Bauman JE
JournalCurr Treat Options Oncol
Volume22
Issue6
Pagination52
Date Published2021 May 15
ISSN1534-6277
KeywordsChemoprevention, Head and Neck Neoplasms, Humans, Immune Checkpoint Inhibitors, Immunomodulation, Life Style, Nicotiana, Precision Medicine, Squamous Cell Carcinoma of Head and Neck
Abstract

To date, there is no FDA-approved chemoprevention approach for tobacco-related HNSCC. Effective chemoprevention approaches validated in sufficiently powered randomized trials are needed to reduce the incidence and improve survival. In this review, we recap the challenges encountered in past chemoprevention trials and discuss emerging approaches, with major focus on green chemoprevention, precision prevention, and immunoprevention. As our current depth of knowledge expands in the arena of cancer immunotherapy, the field of immunoprevention is primed for new discoveries and successes in cancer prevention.
DOI10.1007/s11864-021-00848-x
Alternate JournalCurr Treat Options Oncol
PubMed ID33991232
PubMed Central IDPMC8122210
Grant ListHHSN261201200031C / CA / NCI NIH HHS / United States
HHSN261201200031I / CA / NCI NIH HHS / United States
UG1 CA242596 / CA / NCI NIH HHS / United States
Faculty Reference: 
Carlos Caulin, PhD