|Title||The Role of Targeted Therapy in the Management of Sinonasal Malignancies.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Kashat L, Le CH, Chiu AG|
|Journal||Otolaryngol Clin North Am|
|Date Published||2017 Apr|
|Keywords||Carcinoma, Squamous Cell, Combined Modality Therapy, Humans, Immunity, Cellular, Immunotherapy, Melanoma, Molecular Targeted Therapy, Paranasal Sinus Neoplasms, Skull Base|
Cancers develop secondary to genetic and epigenetic changes that provide the cell with a survival advantage that promotes cellular immortality. Malignancy arises when tumors use mechanisms to evade detection and destruction by the immune system. Many malignancies seem to elicit an immune response, yet somehow manage to avoid destruction by the cells of the immune system. Cancers may evade this immune response by numerous mechanisms. Several targeted immune therapies are available that block some of these inhibitory signals and enhance the cell-mediated immune response. Many of these agents hold significant promise for future treatment of sinonasal and ventral skull base malignancies.
|Alternate Journal||Otolaryngol Clin North Am|
The Role of Targeted Therapy in the Management of Sinonasal Malignancies.
Christopher Le, MD, FACS