The Role of Targeted Therapy in the Management of Sinonasal Malignancies.

TitleThe Role of Targeted Therapy in the Management of Sinonasal Malignancies.
Publication TypeJournal Article
Year of Publication2017
AuthorsKashat L, Le CH, Chiu AG
JournalOtolaryngol Clin North Am
Volume50
Issue2
Pagination443-455
Date Published2017 Apr
ISSN1557-8259
KeywordsCarcinoma, Squamous Cell, Combined Modality Therapy, Humans, Immunity, Cellular, Immunotherapy, Melanoma, Molecular Targeted Therapy, Paranasal Sinus Neoplasms, Skull Base
Abstract

Cancers develop secondary to genetic and epigenetic changes that provide the cell with a survival advantage that promotes cellular immortality. Malignancy arises when tumors use mechanisms to evade detection and destruction by the immune system. Many malignancies seem to elicit an immune response, yet somehow manage to avoid destruction by the cells of the immune system. Cancers may evade this immune response by numerous mechanisms. Several targeted immune therapies are available that block some of these inhibitory signals and enhance the cell-mediated immune response. Many of these agents hold significant promise for future treatment of sinonasal and ventral skull base malignancies.

DOI10.1016/j.otc.2016.12.016
Alternate JournalOtolaryngol Clin North Am
PubMed ID28314406
Faculty Reference: 
Christopher Le, MD, FACS