The Role of Viruses in the Inception of Chronic Rhinosinusitis.

TitleThe Role of Viruses in the Inception of Chronic Rhinosinusitis.
Publication TypeJournal Article
Year of Publication2022
AuthorsLee HSeung, Volpe SJ, Chang EH
JournalClin Exp Otorhinolaryngol
Volume15
Issue4
Pagination310-318
Date Published2022 Nov
ISSN1976-8710
Abstract

Chronic rhinosinusitis (CRS) is a complex inflammatory disorder that affects between 2% and 16% of adults in the United States, with estimated healthcare costs between 4 and 12 million USD. Viruses are a common etiologic factor for URIs, are frequently identified in the sinuses of patients with CRS, and trigger CRS exacerbations. Therefore, investigating the role of viruses provides an opportunity to identify their role in the pathogenesis of CRS. In this review, we identified the viruses frequently isolated in patients with CRS, as well as their associated immunologic responses and contributions to inflammation. Rhinovirus, parainfluenza virus, influenza virus, and respiratory syncytial virus are the viruses commonly found in patients with CRS. This information allows us to target pathways early in the pathogenesis of CRS, thereby playing a significant role in slowing the progression of this chronic disease.

DOI10.21053/ceo.2022.01004
Alternate JournalClin Exp Otorhinolaryngol
PubMed ID36455880
PubMed Central IDPMC9723285
Faculty Reference: 
Eugene H. Chang, MD