|Title||Spontaneous Resolution of Cholesteatoma in a Patient on Long-Term Infliximab.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Chao J, Dewyer N, McKenna MJohn|
|Journal||Ann Otol Rhinol Laryngol|
|Date Published||2019 Apr|
|Keywords||Antibodies, Monoclonal, Cholesteatoma, Corneal Opacity, Drug Repositioning, Female, Foreign-Body Reaction, Humans, Infliximab, Middle Aged, Ophthalmologic Surgical Procedures, Prosthesis Implantation, Remission, Spontaneous, Stevens-Johnson Syndrome, Temporal Bone, Tomography, X-Ray Computed, Treatment Outcome, Tumor Necrosis Factor-alpha|
OBJECTIVE:: To describe an observed case of spontaneous regression of cholesteatoma in a patient on chronic anti-tumor necrosis factor-alpha (TNF-a) therapy and inspire further research into the role of TNF-a in cholesteatoma.
METHODS:: Clinical assessment of disease in a single-patient case report.
RESULTS:: A 49-year-old woman suffered a severe case of Stevens-Johnson syndrome when she was 12 years old, leaving her with bilateral corneal opacification and tympanic membrane perforations with extensive cholesteatoma. For her corneal opacification, a corneal prosthesis was placed, which was complicated by a foreign body reaction necessitating long-term therapy with infliximab, a monoclonal antibody against TNF-a that is therapeutic in some chronic inflammatory diseases. She was otherwise healthy and took no other medications. While on infliximab, the patient had spontaneous and complete resolution of her cholesteatoma without any surgical intervention.
CONCLUSIONS:: This surprising case suggests that there may be a prominent role of TNF-a in cholesteatoma pathophysiology and that TNF-a may be an effective target for nonsurgical therapy.
|Alternate Journal||Ann Otol Rhinol Laryngol|
Spontaneous Resolution of Cholesteatoma in a Patient on Long-Term Infliximab.
Nicholas Dewyer, MD