Eugene H. Chang, MD

Associate Professor, Otolaryngology
Director, Rhinology

Eugene H. Chang, MD, FACS is a surgeon-scientist with a clinical and research focus in endoscopic sinus and skull base surgery. His clinical practice includes primary and revision endoscopic sinus surgery, endoscopic cerebrospinal fluid (CSF) leak repair, and skull base tumor surgery. He completed his medical school training at Brown University in the Program for Liberal Medical Education (PLME), and proceeded to complete his residency and fellowship at the University of Iowa, which has been ranked in the top ten otolaryngology training programs over the past twenty five years. Dr. Chang became an assistant professor in the Department of Otolaryngology-Head and Neck surgery at the University of Iowa, and since beginning his academic practice has consistently been funded by the National Institute of Health (NIH) for his work in translational sinus research. He is one of a small number of surgeon-scientists in Otolaryngology that combines an active clinical practice and research expertise to help understand the basic process of sinus disease and develop future therapies and treatments. Dr. Chang is the associate editor for the Rhinology and Skull base section of the Annals of Otolaryngology and the author of over thirty peer-reviewed manuscripts. His clinical and research expertise has been recognized by the NIH, the International Rhinology society, and the Cystic Fibrosis Foundation. He is a Fellow of the American College of Surgeons (FACS). Dr. Chang's clinical specialties are endoscopic and minimally invasive techniques to remove benign and malignant tumors of the nose, sinuses, and skull base, including: Frontal sinus surgery Revision endoscopic sinus surgery Endoscopic repair of cerebrospinal fluid (CSF) leaks Endoscopic sinonasal tumor surgery

Research Interests

Dr. Chang’s research is divided into three areas. Cystic fibrosis (CF) research: Dr. Chang is investigating the role of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in the pathogenesis of chronic sinusitis. He published the first animal model of CF sinus disease, and has characterized novel therapies including gene therapy vectors and CFTR potentiators in improving CF sinus disease in both animals and humans. Sinus microbiome research: the “microbiome” is the microbial community that is present in the human body. The sinonasal cavities have traditionally been thought to be sterile cavities, but new research is beginning to elucidate the vast number of microbial communities that populate our sinus. With this knowledge, we are investigating how our current therapies can influence this microbial population and prevent sinus disease. Impact of the upper and lower airway: as otolaryngologists, our focus has been in the airway of the head and neck. Dr. Chang has been investigating how the upper airway can influence disease of the lower airway, and vice versa. This research can influence the understanding of common diseases of the lower airway, such as asthma and chronic obstructive pulmonary disease (COPD). Dr. Chang receives active funding research support from the NIH, and the Cystic Fibrosis Foundation.

Education and Training

MD: Brown Medical School
University of Iowa Hospital and Clinics
University of Iowa Hospital and Clinics
NIH-T32 Sinonasal research fellowship